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Common metabolites have been implicated as thecausative agents, with 2,5-hexanedione and 2,6-heptanedioneas toxic degradation products of hexane and heptane, respec-tively. By fitting each patient’s data in the per-spective of the concentrations from the other patients, the most likely concentration–timecourse in bone and serum and the AUC can be predicted for each patient By fitting each patient’s data in the per-spective of the concentrations from the other patients, the most likely concentration–timecourse in bone and serum and the AUC can be predicted for each patient.
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